Continuous Jostling Helps Protein Perform

Randomization helps to perform independent tasks reliably

This paper is about algorithms that schedule tasks to be performed in a distributed failure-prone environment, when processors communicate by message-passing, and when tasks are independent and of unit length. The processors work under synchrony and may fail by crashing. Failure patterns are imposed by adversaries. The question how the power of adversaries affects the optimality of randomized a...

ERBB2 oncogenicity: ERBIN helps to perform the job

ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) is an oncogenic tyrosine kinase receptor that is overexpressed in breast cancer. Antibodies and inhibitors targeting ERBB2 are currently available, although therapeutic failures remain frequent. We discuss here recent data showing that the scaffold protein ERBB2IP (ERBB2 interacting protein, best known as ERBIN) regulates E...

Randomization Helps to Perform Tasks on Processors Prone to Failures

Jostling for position in angiogenic sprouts: continuous rearrangement of cells explained by differential adhesion dynamics.

Endothelial sprouting during angiogenesis is a highly coordinated morphogenetic process that involves polarized tip cells leading stalk cells to form new capillaries. While tip and stalk cells previously were thought to be stable and have static phenotypes within the sprout, it is becoming increasingly clear that endothelial cells undergo dynamic rearrangements. A new study using computer simul...

Randomization Helps to Perform Tasks on Pro essors Prone to Failures